RAD 150 BENZOATE TRIAL

The latest SARM to hit shelves in the UK is RAD-150, also known as TLB-150 Benzoate. That means they only bind to muscle tissue androgen receptors and leave the rest of your body alone. But unlike steroids, SARMs don’t cause systematic effects. Selective androgen receptor modulators (SARMs) are tissue-selective research drugs similar to steroids. With its predecessor RAD-140 taking the top spot when it comes to best-selling SARMs, everyone is wondering how RAD-150 compares and why its rapidly gaining the same level of popularity.

Norethisterone esters (e.g.RAD-150 is the latest compound gaining all the attention when it comes to research chemicals and the bodybuilding industry.

Levonorgestrel esters (e.g., levonorgestrel butanoate).17α-Ethynyl-19-nortestosterone derivatives: Δ 4-Tibolone.5α-Dihydro-17α-ethynyltestosterone derivatives: 17α-Ethynyl-3α-androstanediol.17α-Ethynyltestosterone derivatives: Danazol.17α-Vinyl-19-nortestosterone derivatives: Vinyltestosterone.17α-Vinyltestosterone derivatives: Norvinisterone (vinylnortestosterone).17α-Alkylated 5α-dihydro-19-nortestosterone derivatives: 5α-Dihydronorethandrolone.17α-Alkylated 19-nortestosterone derivatives: Bolenol.17α-Alkylated 5α-dihydrotestosterone derivatives: Androisoxazole.Methyltestosterone ( +esterified estrogens).Methylclostebol (chloromethyltestosterone).Chlorodehydromethylandrostenediol (CDMA).17α-Alkylated testosterone derivatives: Bolasterone.5α-Dihydro-19-nortestosterone derivatives: 5α-Dihydronandrolone.Oxabolone cipionate (oxabolone cypionate).Normethandrone (methylestrenolone, normethisterone).LS-1727 (nandrolone 17β- N-(2-chloroethyl)- N-nitrosocarbamate).11β-Methyl-19-nortestosterone dodecylcarbonate.19-Nortestosterone derivatives: 7α-Methyl-19-norandrostenedione (MENT dione, trestione).Dihydrotestosterone (DHT) ( androstanolone, stanolone).5α-Dihydrotestosterone derivatives: 1-Androstenediol.DHEA (androstenolone, prasterone 5-DHEA).Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione).Testosterone derivatives: 4-Androstenediol.'Drug-Induced Liver Injury by Selective Androgenic Receptor Modulators'.

^ Flores JE, Chitturi S, Walker S (March 2020).

RAD 150 BENZOATE TRIAL

^ Clinical trial number NCT03088527 for 'Phase 1, First-in-Human Study of RAD140 in Postmenopausal Women With Breast Cancer' at.'Abstract P5-11-01 : Phase 1 dose escalation study of a novel selective androgen receptor modulator (SARM), RAD140, in estrogen receptor positive (ER ), human epidermal growth factor receptor 2 negative (HER2-), metastatic breast cancer'. ^ Hamilton E, LoRusso P, Ma C, Vidula N, Bagley RG, Troy S, et al.'Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action'. ^ Yu Z, He S, Wang D, Patel HK, Miller CP, Brown JL, et al.'Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140'. ^ Miller CP, Shomali M, Lyttle CR, O'Dea LS, Herendeen H, Gallacher K, et al.'Androgens increase survival of adult-born neurons in the dentate gyrus by an androgen receptor-dependent mechanism in male rats'. ^ Hamson DK, Wainwright SR, Taylor JR, Jones BA, Watson NV, Galea LA (September 2013).'Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats'. ^ Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ (April 2014).RAD 140 slightly increased lean muscle mass when used in primates, by targeting androgen receptors in skeletal tissue. RAD 140 appears to be safer than testosterone replacement therapy (TRT) in rats. In early 2020 a single case report of drug-induced liver injury following use of RAD 140 was published.

The first-in-human study was initiated in October of 2017 and completed in September 2020 in postmenopausal women with breast cancer. Some of the potential benefits under investigation are for the treatment of conditions such as muscle wasting and bone loss. It was licensed to Ellipses Pharmaceuticals in 2020. RAD140 is an investigational selective androgen receptor modulator (SARM) that is developed by Radius Health, Inc.

Rad 150 benzoate